Positively charged

Amplifying possibilities with a new class of treatment
for chronic cough and other diseases of sensory 
neuron hypersensitivity 
May 5, 2026 Nocion Therapeutics Announces Full Enrollment in Phase 2b ASPIRE Study of Taplucainium for Chronic Cough

Our mission is to bring long-awaited relief to people with chronic cough and other diseases of sensory neuron hypersensitivity with a new class of charged sodium channel blockers

Nine million Americans live with a chronic cough that persists despite treatment or has no identifiable cause. Chronic cough is one of the most common reasons people visit a physician in the U.S., and remains one of the least effectively treated conditions with no new therapies approved in more than 60 years. Nocion’s mission is to change that. We are developing taplucainium, a first-in-class inhaled therapy designed to silence the nerve signaling that drives refractory and unexplained chronic cough at its source. Nocion is also leveraging its foundational scientific platform to develop new medicines to address other debilitating chronic conditions where overactive sensory nerves cause lasting harm.

Chronic cough

Chronic cough: 

A disease of sensory neuron hypersensitivity

Millions of people cough every hour of every day, with no effective treatment. Learn more about refractory and unexplained chronic cough.

First-in-class approach now in Phase 2b clinical development

Our Phase 2b ASPIRE study of taplucainium is fully enrolled, with topline results expected in Q3 2026.

Nocions™ selectively 
silence activated 
nociceptors

Many chronic conditions are driven by sensory neurons that are overactive or hypersensitive. Our nocion platform is designed to silence them – selectively, locally, and durably.